Scientific Publications

DecisionDx®-SCC Clinical Evidence

Ibrahim S, Kasprzak J, Hall M et al. Enhanced metastatic risk assessment in cutaneous squamous cell carcinoma with the 40-gene expression profile test. Future Oncology 2021. doi:

Wysong, A, Newman J, Covington K et al. Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma. JAAD 2021; 361-368. doi:

Arron S, Wysong A, Hall M, et al. Gene expression profiling for metastatic risk in head and neck cutaneous squamous cell carcinoma. Laryng Investig Oto 2022; 1-10. doi:

Borman S, Wilkinson J, Meldi-Sholl L et al. Analytical validity of DecisionDx-SCC, a gene expression profile test to identify risk of metastasis in cutaneous squamous cell carcinoma (SCC) patients. Diagnostic Pathology 2022. doi:

DecisionDx-SCC Clinical Impact Studies and Surveys

Farberg A, Fitzgerald A, Ibrahim S et al. Current Methods and Caveats to Risk Factor Assessment in Cutaneous Squamous Cell Carcinoma (cSCC): A Narrative Review. Dermatol Ther 2022. doi:

Au J, Hooper P, Somani AK et al. Clinical Utility of the 40-Gene Expression Profile (40-GEP) Test for Improved Patient Management Decisions and Disease-Related Outcomes when Combined with Current Clinicopathological Risk Factors for Cutaneous Squamous Cell Carcinoma (cSCC): Case Series. Dermatol Ther 2021. doi:

Arron S, Blalock T, Guenther M, et al. Clinical considerations for integrating gene expression profiling into cutaneous squamous cell carcinoma management. JDD 2021; s5-s10. doi:

Farberg AS, Hall MA, Douglas L, et al. Integrating gene expression profiling into NCCN high-risk cutaneous squamous cell carcinoma management recommendations: Impact on patient management. Curr Med Res Opin 2020. doi:10.1080/03007995.2020.1763284.

Litchman GH, Fitzgerald AL, Kurley SJ, et al. Impact of a prognostic 40-gene expression profiling test on clinical management decisions for high-risk cutaneous squamous cell carcinoma. Curr Med Res Opin 2020. doi:10.1080/03007995.2020.1763283.

Teplitz R, Prado G, Litchman GB, Rigel DS. Impact of gene expression profile testing on the management of squamous cell carcinoma by dermatologistsJ Drugs Dermatol 2019;18:980-4.

Squamous Cell Carcinoma and Melanoma Information

SEER data release 2019.

Mansouri B, Housewright CD. The treatment of actinic keratoses— the rule rather than the exception. JAMA Dermatol 2017;153:1200.

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Overview of SCC

SCC Risk Factors